Is Gabapentin or Pregabalin better for anxiety?

⚪ Clinical pearl: The decision between gabapentin and pregabalin for anxiety involves a direct trade-off between evidence and tolerability. Pregabalin has a clear advantage in efficacy evidence, supported by eight large trials for GAD and social anxiety at doses of 150–600 mg/day. Gabapentin has weaker evidence from two small trials for panic and social anxiety, requiring higher doses of 900–3600 mg/day. However, gabapentin holds a tolerability advantage, with lower rates of weight gain and ataxia. The choice requires a conscious weighing of stronger evidence versus fewer side effects.

🔗 To learn more about this pearl, check out the Carlat Article: https://www.thecarlatreport.com/articles/3628-an-off-label-guide-to-gabapentin