How do the commonly used benzos compare in onset/duration?
Ranked from fastest-acting (and shortest-lasting) to slowest-acting (and longest-lasting):
alprazolam → lorazepam → clonazepam
⚪ Clinical pearl: Diazepam is unique; its lipophilic nature gives it the rare combo of fast onset and a long duration.
🔗 To learn more about this pearl, check out the Carlat Article: https://www.thecarlatreport.com/articles/2721-benzodiazepines-for-anxiety-where-they-fit-in